Constant hepatic ATP concentrations during prolonged fasting and absence of effects of Cerbomed Nemos^® on parasympathetic tone and hepatic energy metabolism.

ABSTRACT:

Objective

Brain insulin-induced improvement in glucose homeostasis has been proposed to be mediated by the parasympathetic nervous system. Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) activating afferent branches of the vagus nerve may prevent hyperglycemia in diabetes models. We examined the effects of 14-min taVNS vs sham stimulation by Cerbomed Nemos^® on glucose metabolism, lipids, and hepatic energy homeostasis in fasted healthy humans (n = 10, age 51 ± 6 yrs, BMI 25.5 ± 2.7 kg/m²).

Methods

Heart rate variability (HRV), reflecting sympathetic and parasympathetic nerve activity, was measured before, during and after taVNS or sham stimulation. Endogenous glucose production was determined using [6,6-²H₂]gl

SUBMITTER: Gancheva S 

PROVIDER: S-EPMC5784324 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature