Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing.

ABSTRACT: OBJECTIVE:To determine the role of fatty acid oxidation on the cellular, molecular, and physiologic response of brown adipose tissue to disparate paradigms of chronic thermogenic stimulation. METHODS:Mice with an adipose-specific loss of Carnitine Palmitoyltransferase 2 (Cpt2A-/-), that lack mitochondrial long chain fatty acid β-oxidation, were subjected to environmental and pharmacologic interventions known to promote thermogenic programming in adipose tissue. RESULTS:Chronic administration of β3-adrenergic (CL-316243) or thyroid hormone (GC-1) agonists induced a loss of BAT morphology and UCP1 expression in Cpt2A-/- mice. Fatty acid oxidation was also required for the browning of white adipose tissue (WAT) and the induction of UCP1 in WAT. In contrast, chronic cold (15 °C) stimulation in

SUBMITTER: Gonzalez-Hurtado E 

PROVIDER: S-EPMC5784326 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature