Duration of the acute hepatic encephalopathy episode determines survival in cirrhotic patients.

ABSTRACT:

Background

Episodes of hepatic encephalopathy (HE) have been related to low survival rate. However, the relation between its clinical evolution and mortality has not been assessed.

Methods

A retrospective analysis of 245 cirrhotic patients admitted for an acute episode of HE (⩾grade 2) or who developed an HE episode after an upper gastrointestinal bleeding (UGIB) event was performed to assess the relation between time in HE and transplant-free survival.

Results

Median (IQR_25-75) time in HE was 48 h (24-96 h) in the whole cohort. Patients who presented a longer time in HE (>48 h; n = 89) exhibited a lower transplant-free survival at 28 days (67.2% versus 88.9%, p < 0.001), 90 days (48.7% versus 73.8%, p < 0.001) and 365 day

SUBMITTER: Ventura-Cots M 

PROVIDER: S-EPMC5784576 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature