Retrospective Molecular Epidemiology Study of PD-L1 Expression in Patients with EGFR-Mutant Non-small Cell Lung Cancer.

ABSTRACT:

Purpose

Data are limited on programmed death ligand 1 (PD-L1) expression in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC).

Materials and methods

We retrospectively evaluated the relationship between PD-L1 expression and recurrence-free survival (RFS) and overall survival in 319 patients with EGFR-mutant NSCLC who were treated at Samsung Medical Center from 2006 to 2014. Membranous PD-L1 expression on tumor cells was measured using the PD-L1 IHC 22C3 pharmDx antibody and reported as tumor proportion score (TPS). Kaplan-Meier methods, log-rank test, and Cox proportional hazards models were used for survival analysis.

Results

All patients had ≥1 EGFR mutation-54% in exon 19 and 39% in exon 21. Overall, 51% of patie

SUBMITTER: Cho JH 

PROVIDER: S-EPMC5784638 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature