Claudin expression during early postnatal development of the murine cochlea.

ABSTRACT:

Background

Claudins are major components of tight junctions, which form the paracellular barrier between the cochlear luminal and abluminal fluid compartments that supports the large transepithelial voltage difference and the large concentration differences of K⁺, Na⁺ and Ca²⁺ needed for normal cochlear function. Claudins are a family of more than 20 subtypes, but our knowledge about expression and localization of each subtype in the cochlea is limited.

Results

We examined by quantitative RT-PCR the expression of the mRNA of 24 claudin isoforms in mouse cochlea during postnatal development and localized the expression in separated fractions of the cochlea. Transcripts of 21 claudin isoforms were detected at all ages, while 3 isoforms (Cldn-16

SUBMITTER: Kudo T 

PROVIDER: S-EPMC5784685 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature