Cerebral metabolic effects of strict versus conventional glycaemic targets following severe traumatic brain injury.

ABSTRACT:

Background

Optimal glycaemic targets for patients with severe traumatic brain injury remain unclear. The primary objective of this microdialysis study was to compare cerebral metabolism with strict versus conventional glycaemic control.

Methods

We performed a prospective single-centre randomised controlled within-subject crossover study of 20 adult patients admitted to an academic neurointensive care unit with severe traumatic brain injury. Patients underwent randomised, consecutive 24-h periods of strict (4-7 mmol/L; 72-126 mg/dl) and conventional (<10 mmol/L; 180 mg/dl) glycaemic control with microdialysis measurements performed hourly. The first 12 h of each study period was designated as a 'washout' period, with the subsequent 12 h being the period of interest.

Result

SUBMITTER: Plummer MP 

PROVIDER: S-EPMC5784688 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature