Maternal and fetal genetic contribution to gestational weight gain.

ABSTRACT:

Background

Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG.

Participants and methods

A genome-wide association study was used to identify maternal and fetal variants contributing to GWG in up to 10 543 mothers and 16 317 offspring of European origin, with replication in 10 660 mothers and 7561 offspring. Additional

SUBMITTER: Warrington NM 

PROVIDER: S-EPMC5784805 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature