Lack of Efficacy of Symptoms and Medical History in Distinguishing the Degree of Eosinophilia in Nasal Polyps.

ABSTRACT:

Background

Distinguishing eosinophilic nasal polyps (NP) from noneosinophilic NP will impact prognosis and therapeutic responsiveness.

Objective

To investigate the ability of clinical history and biomarkers to distinguish these conditions.

Methods

A total of 74 consecutive patients undergoing surgery for NP were enrolled. Clinical presentations were evaluated using the 22-item sinonasal outcome test (SNOT-22). Biomarkers included absolute eosinophil count, IgE, and extent of tissue hyperplasia on sinus computed tomography scan. Tissue eosinophilia was quantified in 10 random hpf and data analyzed addressing both peak and average results.

Results

No component of the SNOT-22 was predictive of tissue eosinophilia. Similarly, a medical history of allergic rhinitis,

SUBMITTER: Steinke JW 

PROVIDER: S-EPMC5784826 | biostudies-literature | 2017 Nov - Dec

REPOSITORIES: biostudies-literature