Human Genetic Adaptation to High Altitudes: Current Status and Future Prospects.

ABSTRACT: The question of whether human populations have adapted genetically to high altitude has been of interest since studies began there in the early 1900s. Initially there was debate as to whether genetic adaptation to high altitude has taken place based, in part, on disciplinary orientation and the sources of evidence being considered. Studies centered on short-term responses, termed acclimatization, and the developmental changes occurring across lifetimes. A paradigm shift occurred with the advent of single nucleotide polymorphism (SNP) technologies and statistical methods for detecting evidence of natural selection, resulting in an exponential rise in the number of publications reporting genetic adaptation. Reviewed here are the various kinds of evidence by which adaptation to high altitude

SUBMITTER: Moore LG 

PROVIDER: S-EPMC5784843 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature