Location, number and factors associated with cerebral microbleeds in an Italian-British cohort of CADASIL patients.

ABSTRACT:

Background and purpose

The frequency, clinical correlates, and risk factors of cerebral microbleeds (CMB) in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) are still poorly known. We aimed at determining the location and number of CMB and their relationship with clinical manifestations, vascular risk factors, drugs, and other neuroimaging features in CADASIL patients.

Methods

We collected clinical data by means of a structured proforma and centrally evaluated CMB on magnetic resonance gradient echo sequences applying the Microbleed Anatomical Rating Scale in CADASIL patients seen in 2 referral centers in Italy and United Kingdom.

Results

We evaluated 125 patients. CMB were present in 34% of patients and their prese

SUBMITTER: Nannucci S 

PROVIDER: S-EPMC5784892 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature