Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial.

ABSTRACT:

Background

Severe malaria is a leading cause of acquired neurodisability in Africa and is associated with reduced nitric oxide (NO) bioavailability. A neuroprotective role for inhaled NO has been reported in animal studies, and administration of inhaled NO in preterm neonates with respiratory distress syndrome is associated with a 47% reduced risk of cognitive impairment at two years of age.

Methods

A randomized double-blind placebo-controlled trial of inhaled NO versus placebo as an adjunctive therapy for severe malaria was conducted in Uganda between 2011 and 2013. Children received study gas for a maximum 72 hours (inhaled NO, 80 parts per million; room air placebo). Neurocognitive testing was performed on children<5 years at 6 month follow-up. The neurocognitive outcomes

SUBMITTER: Bangirana P 

PROVIDER: S-EPMC5784958 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature