Obesity induced alterations in redox homeostasis and oxidative stress are present from an early age.

ABSTRACT: OBJECTIVES:Oxidative stress and inflammation have been postulated as underlying mechanisms for the development of obesity-related insulin resistance. This association however, remains elusive especially in childhood. We sought to investigate this relation by measuring oxidative stress and antioxidant response biomarkers, before and during an oral glucose tolerance test (OGTT), in different biological samples from obese children. SUBJECTS:24 children were recruited for the study, (18 obese and 6 controls). After OGTT, the obese group was subdivided in two, according to whether or not carbohydrate metabolic impairment (Ob.IR+, Ob.IR-; respectively) was found. Different biomarkers were analyzed after fasting (T = 0) and during an OGTT (T = 60 and 120 min). Lipoperoxides were measured in plasm

SUBMITTER: Lechuga-Sancho AM 

PROVIDER: S-EPMC5784965 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature