Modeling the assembly order of multimeric heteroprotein complexes.

ABSTRACT: Protein-protein interactions are the cornerstone of numerous biological processes. Although an increasing number of protein complex structures have been determined using experimental methods, relatively fewer studies have been performed to determine the assembly order of complexes. In addition to the insights into the molecular mechanisms of biological function provided by the structure of a complex, knowing the assembly order is important for understanding the process of complex formation. Assembly order is also practically useful for constructing subcomplexes as a step toward solving the entire complex experimentally, designing artificial protein complexes, and developing drugs that interrupt a critical step in the complex assembly. There are several experimental methods for determining

SUBMITTER: Peterson LX 

PROVIDER: S-EPMC5785014 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature