Review article: the pathogenesis of pouchitis.

ABSTRACT:

Background

A total proctocolectomy followed by ileal pouch-anal anastomosis is a potentially curative surgery for ulcerative colitis or familial adenomatous polyposis. About 5-35% of patients with ulcerative colitis and 0-11% of patients with familial adenomatous polyposis develop subsequent inflammation of the ileal pouch termed pouchitis.

Aim

To provide a comprehensive analysis of the research studying the possible pathogenesis of pouchitis. The goals were to identify promising areas of investigation, to help focus clinicians, researchers and patients on how to better understand and then potentially manage ileal pouchitis, and to provide avenues for future research investigations.

Methods

This review examined manuscripts from 1981 to 2015 that discussed and/or propo

SUBMITTER: Schieffer KM 

PROVIDER: S-EPMC5785099 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature