Natural changes in light interact with circadian regulation at promoters to control gene expression in cyanobacteria.

ABSTRACT: The circadian clock interacts with other regulatory pathways to tune physiology to predictable daily changes and unexpected environmental fluctuations. However, the complexity of circadian clocks in higher organisms has prevented a clear understanding of how natural environmental conditions affect circadian clocks and their physiological outputs. Here, we dissect the interaction between circadian regulation and responses to fluctuating light in the cyanobacterium Synechococcus elongatus. We demonstrate that natural changes in light intensity substantially affect the expression of hundreds of circadian-clock-controlled genes, many of which are involved in key steps of metabolism. These changes in expression arise from circadian and light-responsive control of RNA polymerase recruitme

SUBMITTER: Piechura JR 

PROVIDER: S-EPMC5785211 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature