Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles.

ABSTRACT: The human lung harbors a large population of resident memory T cells (Trm cells). These cells are perfectly positioned to mediate rapid protection against respiratory pathogens such as influenza virus, a highly contagious respiratory pathogen that continues to be a major public health burden. Animal models show that influenza-specific lung CD8+ Trm cells are indispensable for crossprotection against pulmonary infection with different influenza virus strains. However, it is not known whether influenza-specific CD8+ Trm cells present within the human lung have the same critical role in modulating the course of the disease. Here, we showed that human lung contains a population of CD8+ Trm cells that are highly proliferative and have polyfunctional progeny. We observed that different influenza

SUBMITTER: Pizzolla A 

PROVIDER: S-EPMC5785253 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature