Biological underpinnings of an internalizing pathway to alcohol, cigarette, and marijuana use.

ABSTRACT: There is a limited understanding as to how specific genes impact addiction risk. Applying a developmental framework and research domain criteria (RDoC) to identify etiological pathways from genetic markers to addiction may have utility. Prior research has largely focused on externalizing pathways to substance use. Although internalizing mechanisms have received less attention, there is strong support that addiction is a longer term consequence of using substances to cope with internalizing as well as externalizing problems. This study tests whether temperament and depression mediate the association between specific genetic variants and substance use. The sample consisted of 426 adolescents from the Michigan Longitudinal Study (70.9% boys, 84.0% White). Four specific genetic variants were e

SUBMITTER: Trucco EM 

PROVIDER: S-EPMC5785427 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature