Sex Differences in Hemodynamic and Microvascular Mechanisms of Myocardial Ischemia Induced by Mental Stress.

ABSTRACT:

Objective

To investigate sex-specific vascular mechanisms for mental stress-induced myocardial ischemia (MSIMI).

Approach and results

Baseline data from a prospective cohort study of 678 patients with coronary artery disease underwent myocardial perfusion imaging before and during a public speaking stressor. The rate-pressure product response was calculated as the difference between the maximum value during the speech minus the minimum value during rest. Peripheral vasoconstriction by peripheral arterial tonometry was calculated as the ratio of pulse wave amplitude during the speech over the resting baseline; ratios <1 indicate a vasoconstrictive response. MSIMI was defined as percent of left ventricle that was ischemic and as a dichotomous variable. Men (but not women) with

SUBMITTER: Sullivan S 

PROVIDER: S-EPMC5785428 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature