Ontology highlight
ABSTRACT:
SUBMITTER: Bakhoum SF
PROVIDER: S-EPMC5785464 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Nature 20180117 7689
Chromosomal instability is a hallmark of cancer that results from ongoing errors in chromosome segregation during mitosis. Although chromosomal instability is a major driver of tumour evolution, its role in metastasis has not been established. Here we show that chromosomal instability promotes metastasis by sustaining a tumour cell-autonomous response to cytosolic DNA. Errors in chromosome segregation create a preponderance of micronuclei whose rupture spills genomic DNA into the cytosol. This l ...[more]