A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors.

ABSTRACT: The extent to which heterogeneity within mesenchymal stem cell (MSC) populations is related to function is not understood. Using the archetypal MSC in vitro surface marker, CD90/Thy1, here we show that 30% of the MSCs in the continuously growing mouse incisor express CD90/Thy1 and these cells give rise to 30% of the differentiated cell progeny during postnatal development. In adulthood, when growth rate homeostasis is established, the CD90/Thy1⁺ MSCs decrease dramatically in number. When adult incisors are cut, the growth rate increases to rapidly re-establish tooth length and homeostasis. This accelerated growth rate correlates with the re-appearance of CD90/Thy⁺ MSCs and re-establishment of their contribution to cell differentiation. A population of Celsr1⁺

SUBMITTER: An Z 

PROVIDER: S-EPMC5785476 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature