Studies on the Proteome of Human Hair - Identification of Histones and Deamidated Keratins.

ABSTRACT: Human hair is laminar-fibrous tissue and an evolutionarily old keratinization product of follicle trichocytes. Studies on the hair proteome can give new insights into hair function and lead to the development of novel biomarkers for hair in health and disease. Human hair proteins were extracted by detergent and detergent-free techniques. We adopted a shotgun proteomics approach, which demonstrated a large extractability and variety of hair proteins after detergent extraction. We found an enrichment of keratin, keratin-associated proteins (KAPs), and intermediate filament proteins, which were part of protein networks associated with response to stress, innate immunity, epidermis development, and the hair cycle. Our analysis also revealed a significant deamidation of keratin type I and II, a

SUBMITTER: Adav SS 

PROVIDER: S-EPMC5785504 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature