Different resuscitation strategies and novel pharmacologic treatment with valproic acid in traumatic brain injury.

ABSTRACT: Traumatic brain injury (TBI) is a leading cause of death in young adults, and effective treatment strategies have the potential to save many lives. TBI results in coagulopathy, endothelial dysfunction, inflammation, cell death, and impaired epigenetic homeostasis, ultimately leading to morbidity and/or mortality. Commonly used resuscitation fluids such as crystalloids or colloids have several disadvantages and might even be harmful when administered in large quantities. There is a need for next-generation treatment strategies (especially in the prehospital setting) that minimize cellular damage, improve survival, and enhance neurological recovery. Pharmacologic treatment with histone deacetylase inhibitors, such as valproic acid, has shown promising results in animal studies of TBI and may

SUBMITTER: Dekker SE 

PROVIDER: S-EPMC5785554 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature