Incorporating Patient Preferences into Estimation of Optimal Individualized Treatment Rules.

ABSTRACT: Precision medicine seeks to provide treatment only if, when, to whom, and at the dose it is needed. Thus, precision medicine is a vehicle by which healthcare can be made both more effective and efficient. Individualized treatment rules operationalize precision medicine as a map from current patient information to a recommended treatment. An optimal individualized treatment rule is defined as maximizing the mean of a pre-specified scalar outcome. However, in settings with multiple outcomes, choosing a scalar composite outcome by which to define optimality is difficult. Furthermore, when there is heterogeneity across patient preferences for these outcomes, it may not be possible to construct a single composite outcome that leads to high-quality treatment recommendations for all patients. We

SUBMITTER: Butler EL 

PROVIDER: S-EPMC5785589 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature