Association between Genetic Variations of MERTK and Chronic Obstructive Pulmonary Disease in Koreans.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease. To date, a large number of clinical studies have been conducted to investigate the association between genetic variations and COPD. However, little is known regarding the genetic susceptibility of Koreans to this disease. MER receptor tyrosine kinase (MERTK) plays important roles in the inhibition of inflammation and in the clearance of apoptotic cells. Here, we investigated the association between genetic variations in MERTK and the development of COPD in Koreans.

Methods

We conducted genetic analysis of MERTK using genomic DNA samples from 87 patients with COPD and 88 healthy controls and compared the frequency of each variation or haplotype between the patient and control groups. Subse

SUBMITTER: Kim WJ 

PROVIDER: S-EPMC5785628 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature