Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women.

ABSTRACT:

Importance

A recently published study of national data by McGrath et al in 2014 showed increased risk of schizophrenia (SCZ) in offspring associated with both early and delayed parental age, consistent with a U-shaped relationship. However, it remains unclear if the risk to the child is due to psychosocial factors associated with parental age or if those at higher risk for SCZ tend to have children at an earlier or later age.

Objective

To determine if there is a genetic association between SCZ and age at first birth (AFB) using genetically informative but independently ascertained data sets.

Design, setting, and participants

This investigation used multiple independent genome-wide association study data sets. The SCZ sample comprised 18 957 SCZ cases and 22 673 contro

SUBMITTER: Mehta D 

PROVIDER: S-EPMC5785705 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature