Risk-adjusted colorectal cancer screening using the FIT and routine screening data: development of a risk prediction model.

ABSTRACT:

Background

The faecal immunochemical test (FIT) is replacing the guaiac faecal occult blood test in colorectal cancer screening. Increased uptake and FIT positivity will challenge colonoscopy services. We developed a risk prediction model combining routine screening data with FIT concentration to improve the accuracy of screening referrals.

Methods

Multivariate analysis used complete cases of those with a positive FIT (⩾20 μg g^-1) and diagnostic outcome (n=1810; 549 cancers and advanced adenomas). Logistic regression was used to develop a risk prediction model using the FIT result and screening data: age, sex and previous screening history. The model was developed further using a feedforward neural network. Model performance was assessed by discrimination and cali

SUBMITTER: Cooper JA 

PROVIDER: S-EPMC5785737 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature