Tetracycline use and risk of incident skin cancer: a prospective study.

ABSTRACT:

Background

Tetracycline is a photosensitising medication that increases skin vulnerability to UV-related damage.

Methods

We prospectively examined tetracycline use and risk of incident melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) based on 213 536 participants from the Nurses' Health Study (NHS), NHS2, and Health Professionals Follow-up Study. Information on ever use of tetracycline was asked via questionnaire. Diagnoses of melanoma and SCC were pathologically confirmed.

Results

Tetracycline use was associated with a modestly increased risk of BCC (n_case=36 377), with a pooled hazard ratio (HR) of 1.11 (95% confidence interval (CI)=1.02-1.21, P-trend=0.05 by duration of use). Tetracycline use was not significantly associated with m

SUBMITTER: Li WQ 

PROVIDER: S-EPMC5785738 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature