Neutrophils: driving progression and poor prognosis in hepatocellular carcinoma?

ABSTRACT:

Background

Irrespective of the underlying aetiology, 90% of hepatocellular carcinomas arise and progress on a background of chronic inflammation. We have explored the independent prognostic value of circulating inflammatory cells.

Methods

Peripheral blood count data sets from 583 consecutive patients presenting to a single UK centre (2000-2010) were analysed for associations with tumour stage, liver function, performance status (PST) and survival. Validation was in an independent Hong Kong cohort (585 patients; 2007-2013).

Results

In both UK and Hong Kong cohorts, neutrophils, platelets, lymphocytes, the neutrophil/lymphocyte ratio (NLR) and the Systemic Immune-Inflammation Index (SII) correlated stepwise, either increasing or decreasing (lymphocytes), with tumour nod

SUBMITTER: Margetts J 

PROVIDER: S-EPMC5785742 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature