Tumour-infiltrating inflammatory and immune cells in patients with extrahepatic cholangiocarcinoma.

ABSTRACT: BACKGROUND:Inflammation and immune characteristics of the tumour microenvironment have therapeutic significance. The aim of this study was to investigate the clinical impact on disease progression in human extrahepatic cholangiocarcinoma (ECC). METHODS:A total of 114 consecutive ECC patients with curative resection between 2000 and 2014 were enrolled. Tumour infiltrating CD66b+ neutrophils (TANs; tumour associated neutrophils), CD163+ M2 macrophages (TAMs; tumour associated macrophages), CD8+ T cells, and FOXP3+ regulatory T cells (Tregs) were assayed by immunohistochemistry, and their relationships with patient clinicopathological characteristics and prognosis were evaluated. RESULTS:Tumour associated neutrophils were inversely correlated with CD8+ T cells (P=0.0001) and positively correl

SUBMITTER: Kitano Y 

PROVIDER: S-EPMC5785749 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature