Phylogeographic diversity and mosaicism of the <i>Helicobacter pylori tfs</i> integrative and conjugative elements.

ABSTRACT:

Background

The genome of the gastric pathogen Helicobacter pylori is characterised by considerable variation of both gene sequence and content, much of which is contained within three large genomic islands comprising the cag pathogenicity island (cagPAI) and two mobile integrative and conjugative elements (ICEs) termed tfs3 and tfs4. All three islands are implicated as virulence factors, although whereas the cagPAI is well characterised, understanding of how the tfs elements influence H. pylori interactions with different human hosts is significantly confounded by limited definition of their distribution, diversity and structural representation in the global H. pylori population.

Results

To gain a global perspect

SUBMITTER: Delahay RM 

PROVIDER: S-EPMC5785829 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature