A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption.

ABSTRACT:

Background

Oral administration of drugs is convenient and shows good compliance but it can be affected by many factors in the gastrointestinal (GI) system. Consumption of food is one of the major factors affecting the GI system and consequently the absorption of drugs. The aim of this study was to develop a mechanistic GI absorption model for explaining the effect of food on fenofibrate pharmacokinetics (PK), focusing on the food type and calorie content.

Methods

Clinical data from a fenofibrate PK study involving three different conditions (fasting, standard meals and high-fat meals) were used. The model was developed by nonlinear mixed effect modeling method. Both linear and nonlinear effects were evaluated to explain the impact of food intake on drug absorption. Similarly

SUBMITTER: Back HM 

PROVIDER: S-EPMC5785874 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature