Epigenetic Therapy in Acute Myeloid Leukemia: Current and Future Directions.

ABSTRACT: Epigenetic modifications affect gene expression without changes in the actual DNA sequence. Two of the most important mechanisms include DNA methylation and histone tail modifications (especially acetylation and methylation). Epigenetic modulation is a part of normal physiologic development; its dysregulation is an important mechanism of pathogenesis of some cancers, including acute myeloid leukemia (AML). Despite significant progress in understanding the pathogenesis of AML, therapeutic options remain quite limited. Technological advances have facilitated understanding of aberrant DNA methylation and histone methylation/acetylation as key elements in the development of AML and uncovered several recurrent mutations in genes important for epigenetic regulation. However, much remains to be l

SUBMITTER: Kim TK 

PROVIDER: S-EPMC5785931 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature