Introducing the new bacterial branch of the RNase A superfamily.

ABSTRACT: Bovine pancreatic ribonuclease (RNase A) is the founding member of the RNase A superfamily. Members of this superfamily of ribonucleases have high sequence diversity, but possess a similar structural fold, together with a conserved His-Lys-His catalytic triad and structural disulfide bonds. Until recently, RNase A proteins had exclusively been identified in eukaryotes within vertebrae. Here, we discuss the discovery by Batot et al. of a bacterial RNase A superfamily member, CdiA-CT^Ykris: a toxin that belongs to an inter-bacterial competition system from Yersinia kristensenii. CdiA-CT^Ykris exhibits the same structural fold as conventional RNase A family members and displays in vitro and in vivo ribonuclease activity. However, CdiA-CT^Ykris shares little to no

SUBMITTER: Cuthbert BJ 

PROVIDER: S-EPMC5786019 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature