Is the association between health-related quality of life and fatigue mediated by depression in patients with multiple sclerosis? A Spanish cross-sectional study.

ABSTRACT: OBJECTIVES:To determine the mediating effects of depression on health-related quality of life and fatigue in individuals with multiple sclerosis (MS). DESIGN:A cross-sectional study. SETTING:Tertiary urban hospital. PARTICIPANTS:One hundred and eight patients (54% women) with MS participated in this study. OUTCOME MEASURES:Demographic and clinical data (weight, height, medication and neurological impairment), fatigue (Fatigue Impact Scale), depression (Beck Depression Inventory-II) and health-related quality of life (Short-Form Health Survey 36) were collected. RESULTS:Fatigue was significantly associated with bodily pain, physical function, mental health and depression. Depression was associated with bodily pain and mental health. The path analysis found direct effects from physical funct

SUBMITTER: Fernandez-Munoz JJ 

PROVIDER: S-EPMC5786117 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature