Gene Turnover and Diversification of the α- and β-Globin Gene Families in Sauropsid Vertebrates.

ABSTRACT: The genes that encode the α- and β-chain subunits of vertebrate hemoglobin have served as a model system for elucidating general principles of gene family evolution, but little is known about patterns of evolution in amniotes other than mammals and birds. Here, we report a comparative genomic analysis of the α- and β-globin gene clusters in sauropsids (archosaurs and nonavian reptiles). The objectives were to characterize changes in the size and membership composition of the α- and β-globin gene families within and among the major sauropsid lineages, to reconstruct the evolutionary history of the sauropsid α- and β-globin genes, to resolve orthologous relationships, and to reconstruct evolutionary changes in the developmental regulation of gene expression. Our comparisons revealed contrast

SUBMITTER: Hoffmann FG 

PROVIDER: S-EPMC5786229 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature