Elevated Proportions of Deleterious Genetic Variation in Domestic Animals and Plants.

ABSTRACT: A fraction of genetic variants segregating in any population are deleterious, which negatively impacts individual fitness. The domestication of animals and plants is associated with population bottlenecks and artificial selection, which are predicted to increase the proportion of deleterious variants. However, the extent to which this is a general feature of domestic species is unclear. Here, we examine the effects of domestication on the prevalence of deleterious variation using pooled whole-genome resequencing data from five domestic animal species (dog, pig, rabbit, chicken, and silkworm) and two domestic plant species (rice and soybean) compared with their wild ancestors. We find significantly reduced genetic variation and increased proportion of nonsynonymous amino acid changes in all

SUBMITTER: Makino T 

PROVIDER: S-EPMC5786255 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature