Implication of molecular vascular smooth muscle cell heterogeneity among arterial beds in arterial calcification.

ABSTRACT: Vascular calcification is a strong and independent predictive factor for cardiovascular complications and mortality. Our previous work identified important discrepancies in plaque composition and calcification types between carotid and femoral arteries. The objective of this study is to further characterize and understand the heterogeneity in vascular calcification among vascular beds, and to identify molecular mechanisms underlying this process. We established ECLAGEN biocollection that encompasses human atherosclerotic lesions and healthy arteries from different locations (abdominal, thoracic aorta, carotid, femoral, and infrapopliteal arteries) for histological, cell isolation, and transcriptomic analysis. Our results show that lesion composition differs between these locations. Femoral

SUBMITTER: Espitia O 

PROVIDER: S-EPMC5786328 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature