Differential Activation of Human Keratinocytes by Leishmania Species Causing Localized or Disseminated Disease.

ABSTRACT: All Leishmania species parasites are introduced into mammalian skin through a sand fly bite, but different species cause distinct clinical outcomes. Mouse studies suggest that early responses are critical determinants of subsequent adaptive immunity in leishmaniasis, yet few studies address the role of keratinocytes, the most abundant cell in the epidermis. We hypothesized that Leishmania infection causes keratinocytes to produce immunomodulatory factors that influence the outcome of infection. Incubation of primary or immortalized human keratinocytes with Leishmania infantum or Leishmania major, which cause visceral or cutaneous leishmaniasis, respectively, elicited dramatically different responses. Keratinocytes incubated with L. infantum significantly increased expression of proinflamma

SUBMITTER: Scorza BM 

PROVIDER: S-EPMC5786447 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature