Effects of exposure to water disinfection by-products in a swimming pool: A metabolome-wide association study.

ABSTRACT:

Background

Exposure to disinfection by-products (DBPs) in drinking water and chlorinated swimming pools are associated with adverse health outcomes, but biological mechanisms remain poorly understood.

Objectives

Evaluate short-term changes in metabolic profiles in response to DBP exposure while swimming in a chlorinated pool.

Materials and methods

The PISCINA-II study (EXPOsOMICS project) includes 60 volunteers swimming 40min in an indoor pool. Levels of most common DBPs were measured in water and in exhaled breath before and after swimming. Blood samples, collected before and 2h after swimming, were used for metabolic profiling by liquid-chromatography coupled to high-resolution mass-spectrometry. Metabolome-wide association between DBP exposures and each metabolic f

SUBMITTER: van Veldhoven K 

PROVIDER: S-EPMC5786667 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature