Logistic Regression of Ligands of Chemotaxis Receptors Offers Clues about Their Recognition by Bacteria.

ABSTRACT: Because of relative simplicity of signal transduction pathway, bacterial chemotaxis sensory systems have been expected to be applied to biosensor. Tar and Tsr receptors mediate chemotaxis of Escherichia coli and have been studied extensively as models of chemoreception by bacterial two-transmembrane receptors. Such studies are typically conducted using two canonical ligands: l-aspartate for Tar and l-serine for Tsr. However, Tar and Tsr also recognize various analogs of aspartate and serine; it remains unknown whether the mechanism by which the canonical ligands are recognized is also common to the analogs. Moreover, in terms of engineering, it is important to know a single species of receptor can recognize various ligands to utilize bacterial receptor as the sensor for wide range o

SUBMITTER: Sagawa T 

PROVIDER: S-EPMC5786873 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature