Immune checkpoint inhibition-related colitis: symptoms, endoscopic features, histology and response to management.

ABSTRACT:

Background

Immune checkpoint inhibitors are successfully introduced as anticancer treatment. However, they may induce severe immune-related adverse events (irAEs). One of the most frequent irAEs is diarrhoea. The main objective of this study was to analyse symptoms (ie, grade of diarrhoea), endoscopic and histological features and response to management in immune checkpoint inhibition-related colitis (IRC).

Patients and methods

We retrospectively analysed patients who developed diarrhoea on checkpoint inhibition and therefore underwent an endoscopy and/or were treated with corticosteroids. Patients were treated between August 2010 and March 2016 for metastatic melanoma or non-small cell lung cancer. Severity of IRC was scored using the endoscopic Mayo score and the van der H

SUBMITTER: Geukes Foppen MH 

PROVIDER: S-EPMC5786923 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature