MicroRNA-146a Overexpression Impairs the Positive Selection during T Cell Development.

ABSTRACT: MicroRNAs play crucial roles in modulating immune system. miR-146a, a potent feedback suppressor of NF-κB signaling, was shown to limit the innate immune response and myelopoiesis in a knockout mouse model. Here, we observed high lymphopoiesis demonstrated as mild splenomegaly and severe lymphadenopathy in a miR-146a transgenic mouse model. Overexpression of miR-146a resulted in enhanced proliferation and reduced apoptosis of T cells. More activated CD4⁺ T cells or effector memory T cells were observed in transgenic mice even under physiological conditions. Importantly, as one of the key steps to generate central tolerance, the positive selection of thymocytes is impaired in transgenic mice, resulting in more CD4⁺CD8⁺ double-positive thymocytes but fewer CD

SUBMITTER: Li Z 

PROVIDER: S-EPMC5787067 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature