Effects of Firing Variability on Network Structures with Spike-Timing-Dependent Plasticity.

ABSTRACT: Synaptic plasticity is believed to be the biological substrate underlying learning and memory. One of the most widespread forms of synaptic plasticity, spike-timing-dependent plasticity (STDP), uses the spike timing information of presynaptic and postsynaptic neurons to induce synaptic potentiation or depression. An open question is how STDP organizes the connectivity patterns in neuronal circuits. Previous studies have placed much emphasis on the role of firing rate in shaping connectivity patterns. Here, we go beyond the firing rate description to develop a self-consistent linear response theory that incorporates the information of both firing rate and firing variability. By decomposing the pairwise spike correlation into one component associated with local direct connections and the oth

SUBMITTER: Min B 

PROVIDER: S-EPMC5787127 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature