Regional Citrate Anticoagulation for Intermittent Hemodialysis in Dogs.

ABSTRACT:

Background

The traditional systemic heparinization used for anticoagulation in extracorporeal therapies may cause fatal complications in animals at risk of bleeding.

Hypothesis/objectives

To develop and validate a protocol of regional citrate anticoagulation (RCA) for intermittent hemodialysis in dogs.

Animals

A total of 172 dogs treated with hemodialysis for acute kidney injury.

Methods

In vitro titration was performed, adding trisodium citrate and calcium chloride to heparinized canine blood. A tentative protocol was used first in 66 treatments with additional heparinization and subsequently in 518 heparin-free treatments. Safety and adequacy of RCA were assessed based on clinical and laboratory monitoring, dialyzer pressure gradient, treatment completion, an

SUBMITTER: Francey T 

PROVIDER: S-EPMC5787180 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature