Metagenomic Investigation of Idiopathic Meningoencephalomyelitis in Dogs.

ABSTRACT:

Background

Meningoencephalomyelitis of unknown origin (MUO) is a common and life-threatening neuroinflammatory disease in dogs. Features of the disease are suggestive of an underlying immune-mediated process, but the association of this disease with a pathogen is still unknown.

Hypothesis/objectives

To search for candidate etiologic agent associated with cases if MUO using next generation metagenomic sequencing.

Animals

Twenty-two dogs diagnosed with either MUO (11/22; 10 CSF and 3 brain), or noninflammatory CNS diseases inconsistent with MUO (11/22; 11 CSF and 2 brain) that served as negative controls.

Methods

A case control study was performed by identifying MUO and non-MUO cases. Samples were blindly processed and then unblinded for comparative analyses. Inc

SUBMITTER: Hoon-Hanks LL 

PROVIDER: S-EPMC5787199 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature