Association of thrombocytosis with COPD morbidity: the SPIROMICS and COPDGene cohorts.

ABSTRACT:

Background

Thrombocytosis has been associated with COPD prevalence and increased all-cause mortality in patients with acute exacerbation of COPD (AECOPD); but whether it is associated with morbidity in stable COPD is unknown. This study aims to determine the association of thrombocytosis with COPD morbidity including reported AECOPD, respiratory symptoms and exercise capacity.

Methods

Participants with COPD were included from two multi-center observational studies (SPIROMICS and COPDGene). Cross-sectional associations of thrombocytosis (platelet count ≥350 × 10⁹/L) with AECOPD during prior year (none vs. any), exertional dyspnea (modified Medical Research Council (mMRC) score ≥ 2), COPD Assessment Test (CAT) score ≥ 10, six-minute-walk distance (6MWD), and St. Geo

SUBMITTER: Fawzy A 

PROVIDER: S-EPMC5787242 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature