Effectiveness and safety of bifidobacteria and berberine in people with hyperglycemia: study protocol for a randomized controlled trial.

ABSTRACT:

Background

Berberine is one of the most important examples of a Chinese traditional medicine that has hypoglycemic effects but there have been no randomized controlled trials of the drug in a larger sample. In addition, the use of probiotic biotherapy to maintain an appropriate intestinal flora may represent an effective early intervention for hyperglycemia. Unfortunately, there has been a shortage of relevant research on this possibility at the population level. This study was designed to determine the hypoglycemic effect and safety of both bifidobacteria and berberine administration to newly diagnosed patients with pre-diabetes or diabetes mellitus.

Methods/design

This is a multicenter, double-blind, randomized, and parallel-controlled study that includes a run-in period o

SUBMITTER: Ming J 

PROVIDER: S-EPMC5787258 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature