Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes.

ABSTRACT:

Background

ETCHbox genes are eutherian-specific homeobox genes expressed during preimplantation development at a time when the first cell lineage decisions are being made. The mouse has an unusual repertoire of ETCHbox genes with several gene families lost in evolution and the remaining two, Crxos and Obox, greatly divergent in sequence and number. Each has undergone duplication to give a double homeodomain Crxos locus and a large cluster of over 60 Obox loci. The gene content differences between species raise important questions about how evolution can tolerate loss of genes implicated in key developmental events.

Results

We find that Crxos internal duplication occurred in the mouse lineage, while Obox duplication was stepwise, gene

SUBMITTER: Royall AH 

PROVIDER: S-EPMC5787275 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature