Developmental constraint through negative pleiotropy in the zygomatic arch.

ABSTRACT:

Background

Previous analysis suggested that the relative contribution of individual bones to regional skull lengths differ between inbred mouse strains. If the negative correlation of adjacent bone lengths is associated with genetic variation in a heterogeneous population, it would be an example of negative pleiotropy, which occurs when a genetic factor leads to opposite effects in two phenotypes. Confirming negative pleiotropy and determining its basis may reveal important information about the maintenance of overall skull integration and developmental constraint on skull morphology.

Results

We identified negative correlations between the lengths of the frontal and parietal bones in the midline cranial vault as well as the zygomatic bone and zygomatic process of the maxilla

SUBMITTER: Percival CJ 

PROVIDER: S-EPMC5787316 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature