OTUD7B upregulation predicts a poor response to paclitaxel in patients with triple-negative breast cancer.

ABSTRACT: Paclitaxel is a first-line chemotherapeutic for patients with breast cancer, particularly triple-negative breast cancer (TNBC). Molecular markers for predicting pathologic responses to paclitaxel treatment is thus urgently needed since paclitaxel resistance is still a clinical issue in treating TNBCs. We investigated the transcriptional profiling of consensus genes in HCC38 (paclitaxel-sensitive) and MDA-MB436 (paclitaxel-resistant) TNBC cells post-treatment with paclitaxel. We found that OTUD7B was downregulated in HCC38 but upregulated in MDA-MB436 cells after paclitaxel treatment at cytotoxic concentrations. Moreover, our data showed that OTUD7B expression causally correlated with IC₅₀ of paclitaxel in a panel of TNBC cell lines. Moreover, we found that OTUD7

SUBMITTER: Chiu HW 

PROVIDER: S-EPMC5787489 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature